Osteoarthritis Rat/Rabbit Model

Pharmatest offers four rat models of OA, including:

  1. MIA model, where OA is caused chemically by intra-articular injection of monoiodoacetate (MIA)
  2. MMT+MCLT model, where OA is caused surgically by medial meniscal tear (MMT)  and medial collateral ligament transection (MCLT)
  3. ACLT model, where OA is caused surgically by anterior cruciate ligament transection (ACLT)
  4. ACLT+pMMx model, where OA is caused surgically by ACLT and partial medial meniscectomy (pMMx)
Pharmatest also offers a rabbit model of pMMx that results in a moderate and progressive form of post-traumatic OA, resembling early onset of OA observed in human patients. In addition, Pharmatest is capable of performing studies with other post-traumatic models in rabbits, including the ACLT model.
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