PRODUCTS
Serum Pre-Clinical CartiLaps® (CTX-II) EIA
Code: AC-08F1
Certification:

Research Use Only

Clinical Area: Animal Research
Type: Manual
Format: ELISA
RUO/IVD: RUO
Number of Tests: 96 (40 samples in duplicate)
Sample Type: Serum, Plasma, Cartilage Explant Culture Supernatant and Synovial Fluid
Sample Volume: 25 µL
Assay Range: 0-300 pg/mL

Unique Features

  • Animal Models of Rheumatoid Arthritis and Osteoarthritis
  • Easy, non-invasive quantification of cartilage degradation
  • Strong association to indexes of joint damage, e.g. cartilage erosion
  • Demonstration of Chondroprotective Effect of Drugs
  • Rapid response to chondroprotective drugs (within 1-2 weeks)
  • Early response in CTX-II is highly correlated to histological endpoints3
  • CTX-II can be quantified in relevant cartilage explant culture supernatant human origin and animal models
  • CTX-II is elevated in both RA and OA rat models
  • CTX-II levels are associated with disease activity in RA and OA, primarily indexes of structural damage2
  • Useful for dynamic monitoring of cartilage in multiple species
  • A complete assay panel supporting bone and cartilage research
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